Organic chemistry – Page 3
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ResearchIntermediate considered ‘too reactive to isolate’ finally tamed
Nitrene species stabilised for three days with careful choice of substituent
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FeatureSparking industry’s interest in electrosynthesis
Using electrons instead of reagents offers many potential benefits, but there are still barriers to overcome, as Rachel Brazil reports
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ResearchClever activation strategy widens access to phosphazene superbases
Superbases stored as stable carboxylate salts – adding epoxide releases their full chemical potential
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ResearchStudy questions sustainability benefits of replacing palladium with nickel in cross-coupling reactions
Common belief that Earth-abundant metals are green replacements for palladium may be misleading
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OpinionWill science ever reach an end?
While the rate of discoveries in any field may slow over time, the frontier creeps ever further
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ResearchSimple preparation method improves access to long-known superacid
Aluminium tris(fluorosulfate) synthesised in a single step
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ResearchSimplified hydroformylation replaces rhodium with base metal
Bench-friendly asymmetric hydroformylation swaps toxic gas and expensive catalyst for cheap reagents and mild conditions
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NewsWhat the dichloromethane ban might mean for university labs in the US
The lab use requirements outlined in the agency’s workplace chemical protection plan are impractical for academic institutions, the ACS says
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ResearchHow A-level chemistry solved the 200-year-old problem with the haloform reaction
Mechanistic analysis reveals unknown steps in undergraduate staple, the haloform reaction
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BusinessPan-cancer approval shows huge potential for antibody–drug conjugates
Enhertu gains approval based on gene expression rather than tumour location
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ResearchPorous organic ‘cage of cages’ crystalline structure predicted by computational modelling
Organic cages have been used as precursors to synthesise higher order porous structures, adding to their functionality while the ability to solution process them is retained.
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Research‘Mechanochemistry strikes again’ – this time for deoxygenating phosphine oxides
Mechanochemical process works in 30 minutes under air to regenerate phosphine reagents
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OpinionLab automation gives me more time at the top of the mountain
Getting back to the bench reminds Derek Lowe how much has changed in 40 years
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FeatureIlluminating antiaromaticity
Aromaticity’s dark alter-ego is ready to emerge into the sunlight. James Mitchell Crow talks to the scientists trying to exploit the instability
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ArticleWater microdroplet chemistry enables catalyst-free Diels–Alder reaction
‘Quasi-benzyne’ radical drives exotic reactivity
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ResearchCould mechanochemistry have saved Abbott Laboratories $250 million?
Ball milling solves problem of disappearing ritonavir polymorph
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ResearchTelling left from right: chirality detection faces up to its weaknesses
New solutions are being found to an enduring problem in chemistry
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ResearchFirst mirror-image cyclodextrins come together ‘like Lego’
L-enantiomers could be more stable than their existing, more common, forms
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ResearchCrystalline cages create unusual ‘touchless’ sensors
Researchers connect chemistry and engineering to create touch-free buttons based on the detection of the skin’s water