Pharmacology and psychoactive substances – Page 3
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PodcastFuranocoumarin
Florence Schechter discovers how a seemingly healthy grapefruit-based breakfast could disrupt your daily drugs
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NewsWhat is 'checkpoint therapy' and why did it win the medicine Nobel prize?
James Allison and Tasuku Honjo released the ‘brakes’ on our immune system to combat cancer
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ResearchBismuth drugs kill bacteria by disrupting metabolism
Scientists throw kitchen sink of omics techniques at understanding complicated response of prevalent human pathogen to bismuth drug
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NewsWHO gears up to solve the world’s antivenom crisis
Clinical trials planned to take on scourge of substandard, untested medicines
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ResearchBrain chemistry hints at how obesity impairs antidepressants
Histamine released in response to obesity or bacterial toxins prevents benefits from SSRIs – and that drugs that target these inflammatory signals may restore them
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ResearchNew theory for why lithium helps bipolar patients
Molecular insight could help researchers design mood stabilisers with fewer side effects
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ResearchNicotine degrading enzyme could help smokers quit
Enzyme removes nicotine from blood before it can stimulate brain’s reward system
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ResearchTagging drugs with heavy hydrogen made as easy as flicking a light switch
Photoredox reaction simplifies metabolism studies by swapping hydrogen for deuterium or tritium
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ResearchHow total synthesis is creating antibiotics
Macrolide synthesis could reinvigorate the antibiotic pipeline
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FeatureHow ketamine could help treat severe depression
Nina Notman looks at how the party drug ketamine may hold the key to treating patients with severe depression
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FeatureDeal or no deal?
Clare Sansom highlights recent changes in the landscape of pharma company collaborations and acquisitions
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ResearchMolecular structure is teixobactin’s pièce de résistance
Study builds scientists’ arsenal against drug-resistant superbugs
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ResearchCrystal structure lifts lid on LSD’s secrets
Structure of hallucinogen bound to a human serotonin receptor could explain LSD’s potent and long-lasting effects
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FeatureNew opioid drugs
Creating powerful new painkillers is a constant battle against side-effects – particularly addictions. James Mitchell Crow reports
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OpinionRestarting the mental health pipeline
The lack of UK investment in new drugs for mental health disorders is a problem – but the tide may be about to turn
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CareersThe trials and tribulations of drug discovery
The many pitfalls medicinal chemists face when creating a new drug
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OpinionWe need a global plan to beat resistance
We all need to do our bit and act for the common good if we’re going to protect antibiotics