Reaction mechanisms
The latest chemistry news and research on reaction mechanisms, including kinetic studies, physical organic chemistry and biochemical mechanisms, from the Royal Society of Chemistry's magazine, Chemistry World
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ResearchSynthetic strategies overcome Bredt’s rule, unlocking complex bridgehead alkenes
Two research groups propose new synthetic strategies for making ‘impossible’ molecules, defying a 100-year-old bonding rule
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ResearchNew database unlocks predictive power of radical polarity
Resource could help reduce trial and error in synthesis
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ResearchForce-sensitive molecule pulled apart to create highly reactive aryne
High-intensity ultrasound initiates formal retro-[2+2] cycloaddition by stretching a benzocyclobutene core from strategically placed anchor points
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ResearchDesigner ylide transfers single carbon atoms
Single-atom carbon transfer reagent provides the latest breakthrough in skeletal editing
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ResearchElectrochemical reaction outcomes controlled by customised AC waveforms
Programmed alternating currents allow researchers to choose between reaction mechanisms with the flick of a switch
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ResearchHow A-level chemistry solved the 200-year-old problem with the haloform reaction
Mechanistic analysis reveals unknown steps in undergraduate staple, the haloform reaction
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FeatureIlluminating antiaromaticity
Aromaticity’s dark alter-ego is ready to emerge into the sunlight. James Mitchell Crow talks to the scientists trying to exploit the instability
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ArticleWater microdroplet chemistry enables catalyst-free Diels–Alder reaction
‘Quasi-benzyne’ radical drives exotic reactivity
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ResearchEnergetically unfavourable Diels-Alder reaction driven by chemical fuel
Carbodiimide fuel powers rare, thermodynamically unpromising reaction between diene and dienophile
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ResearchMachine learning could ‘change the paradigm’ for polaritonic chemistry
Model reveals influence of vibrational strong coupling during light-driven reaction
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ResearchIon-beam experiments probe fundamentals of hydronium–hydroxide neutralisation
Researchers uncover new insights into one of chemistry’s most fundamental equilibrium reactions
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ResearchPlasma–microdroplet fusion enables catalyst-free amine alkylations
Microdroplet chemistry improves selectivity of plasma-mediated alkylation reactions
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ResearchUnexpected oscillations clarify mechanism of 100 year-old Fischer–Tropsch reaction
Discovery could pave the way to improved design of catalysts
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ResearchElectrophilic aromatic bromination study casts doubt on textbook intermediate
New computational evidence that electrophilic aromatic bromination actually occurs via an addition–elimination mechanism
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ResearchPolymer upcycling strategy adds azide groups with electrocatalysis
Azido-modifications serve as diversification points for click transformations
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ResearchFormation of chiral centres monitored in real time
Michael addition observed at single-molecule level
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ResearchCharge-transfer interactions during C–H activation directly observed
New insights could guide the design of better catalysts
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FeatureEditing the structure of molecules
Nina Notman meets the chemists expanding the toolbox of reactions capable of adding, deleting and switching single atoms in rings at the heart of organic molecules
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ResearchSurprise as electric fields found to cleave bond homolytically
Study also uncovers that the reaction rate in a field increases linearly with the solvent dielectric constant