All Reactions and synthesis articles – Page 12
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ResearchEngineered enzyme speeds up sedate organic reaction
Biochemical optimisation applied to the Morita–Hillman–Baylis reaction
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ResearchEvolved enzymes carry out new-to-nature radical chemistry
Directed evolution produces enzymes that can ‘tame’ radical intermediates for asymmetric catalytic reactions
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FeatureWiring up organic synthesis
James Mitchell Crow talks to the organic chemists using electrochemistry to add or remove electrons to their molecules at the flick of a switch
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ResearchLow temperature method for decarbonising limestone locks carbon dioxide up as a mineral
Process could drastically cut carbon emissions associated with manufacturing cement
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Research40-year-old mystery of why some molecules break all cyclisation rules has been solved
Molecules that blatantly violate Woodward–Hoffmann rules could lead to general theory of cyclisation in polar compounds
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ResearchGreen credentials of crystallisation process turned around by rotary cone dryer tweak
Mechanochemistry helps transformations and cocrystallisations cut solvent use on an industrial scale
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NewsChemistry Nobel laureate Robert Grubbs dies at 79
US chemist shared 2005 prize for his role in developing the metathesis method in organic synthesis
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NewsThe curious incident of the catalytic amine that never was
A series of unfortunate events and a missed control experiment meant palladium sneaked its way into a supposedly amine-catalysed reaction
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WebinarUsing flow chemistry to give early drug discovery processes a boost
Discover how pioneering modular flow chemistry technologies can unlock the potential for discovery chemists to accelerate research
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ResearchMashed magnesium used to prepare Grignards without worrying about air
Mechanochemical method avoids inert gas and dry solvents in classic organometallic reaction
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ResearchRare red californium sandwich pushes frontier of isolable molecules
Researchers rehearsed metallocene’s synthesis with other elements before using just two milligrams of the precious radioactive actinide
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ResearchDiels-Alder reaction directly observed under the microscope
Simple ring-forming reaction followed on a surface for the first time using scanning probe microscopy
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ResearchPorous material made by mimicking deep Earth conditions
Extreme temperature changes water’s properties so it can replace organic solvent
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ResearchRecord-breaking hexagon made out of fused aromatic rings
90 rings form the largest structure of its kind ever made
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ResearchDearomatisation, but without nasty reagents
New Birch reduction protocol creates solvated electrons without the dangerous combination of liquid ammonia and alkali metal
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ResearchGlassware found to promote reactions in Miller–Urey 'primordial soup' experiment
By running their famous 1952 experiment in glass flasks, Stanley Miller and Harold Urey might have unintentionally simulated the role of rocks on early Earth
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ResearchAre organic chemists discovering fewer reactions than they were decades ago?
Analysis of millions of transformations reveals reliance on popular methods – and the rise of complex reactions
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ResearchPlasma-based approach leads to more reactive oxygen donors for alkene epoxidation
Yield of epoxidation reaction increased, and waste reduced, by using CO2-derived atomic oxygen and plasma-based conditions
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ResearchClippanes join rotaxanes and catenanes in mechanically interlocked molecule family
Keck-clip molecules consist of two entangled gold–carbene metallotweezers
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ResearchCooking oils work as solvents for metal-catalysed reactions
Suzuki–Miyaura, Hiyama, Stille, Sonogashira and Heck cross-couplings shown to proceed with quantitative yields in certain vegetable oils, fish oil, butter and waxes