All Reactions and synthesis articles – Page 13
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FeatureHow organocatalysis won the Nobel prize
Jamie Durrani tells the story of how two young upstarts, Ben List and David MacMillan, created a whole new field of catalysis
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ResearchExploiting evolution to explore chemical space shows promise for drug discovery
Using molecular trees – similar to family trees – chemists could predict how products will evolve to make new molecules
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ArticleAstraZeneca explores new frontiers through academic collaborations
The important of partnerships between industry and academia to drive innovation
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ResearchMöbius metallacycles show their aromaticity with textbook reactivity
First electrophilic aromatic substitution reactions with unusual molecules
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ResearchExplainer: why has asymmetric organocatalysis won the chemistry Nobel prize?
In a rather unexpected move by the Nobel committee, this year’s prize in chemistry has been awarded to Benjamin List and David MacMillan
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NewsAsymmetric organocatalysis scoops 2021 chemistry Nobel prize
Benjamin List and David MacMillan recognised for research that makes chemistry greener
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WebinarOptimising battery performance through materials characterisation
Discover how materials understanding is key to optimising the performance of battery technology and explore several key technologies to perform this characterisation
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ResearchPeptide superstructures speed up Michael reaction
A tripeptide that self-assembles into a supramolecular fibres accelerates an asymmetric benchmark reaction by up to 74%
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ResearchUltraphosphates break decades-old anti-branching rule
Discovery of elusive branched phosphates’ unexpected stability means they could have played a role in prebiotic chemistry
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ResearchMethod to make unusual oligonucleotides could be a boon for gene therapy drugs
Synthesis can insert unusual linkages into DNA molecules while rivalling industry standard chemistry in speed and efficiency
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ResearchEnantioselective synthesis of elusive chiral nitrogen compounds discovered by chance
An ‘elegant and simple’ way to make nitrogen stereocentres by supramolecular recognition
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ResearchElectrons in zinc’s filled 3d orbitals can participate in chemical reactions
Super electrophilic trianions accept three additional electrons to support zinc in a +3 oxidation state
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ResearchBlue light squeezes out heteroatoms from small rings
Photochemical ring editing reaction allows complete molecular shape change in a single step
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ResearchGold(III) catalysis transforms protecting group from base-stable to base-labile
Unique orthogonality in a protecting group achieved using a gold-catalysed cyclisation for selective activation and deprotection
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ResearchMolecular cryo-EM discovers error in 25-year-old natural product structure
Nobel prize-winning biomolecule imaging technique adapted to characterise chemical compounds faster and easier than NMR and x-ray
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ResearchPhotocatalyst couples denitrification and water splitting to manage nitrate pollution
Hydrogen gas generated in situ serves as reducing agent
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OpinionAppreciating sterics
How can chemists quantify steric effects when they struggle to define them?
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ResearchMirror image enzyme constructs longest ever mirror DNA strand
Since chirally inverted DNA is more stable than its natural counterpart, it can be used to encode secret messages
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ResearchHeavy-atom quantum tunnelling catalysed with Lewis acids
Lewis acid–base interactions found to increase quantum tunnelling rates of rearrangement reaction
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ResearchSafer fluorination process developed using flow electrochemistry
Automated system for constructing carbon–fluorine bonds quenches fluorine compounds to reduce exposure and risk to lab chemists