Structural biology – Page 2
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ResearchACE2 receptor not essential for Sars-CoV-2 infection, study shows
Fresh understanding linked to evolutionary plasticity of Covid-19 virus
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ResearchDirect imaging reveals individual protein-bound glycans in new detail
Sequences and locations of biomolecule-bound sugar chains studied at the single-molecule level
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OpinionMoving beyond protein structure
Efforts to understand how intrinsically disordered regions interact have produced a variety of answers
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ResearchMutation studies reveal how Antarctic octopus arms itself with cool enzyme
Understanding cold-tolerant enzyme could help with transplant organ preservation
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ResearchCryo-EM scaffold supports imaging of small proteins previously tricky to study
Improved understanding of the structure of small proteins could aid drug designers
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NewsScientists hope to illuminate unknown human proteins with new public database
‘Unknome’ database contains thousands of understudied proteins
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ResearchProtein folding stability set to be unravelled on a massive scale
Technique can analyse a million protein sequences at a time to provide data for machine learning models
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NewsBillionaire professor donates ‘transformative’ sum to protein science institute
$210 million endowment from entrepreneur and Moderna investor Tim Springer will support ongoing research
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ResearchOptical microscopy with Ångström resolution could revolutionise how we see life
Technique can distinguish between details that are just a few atoms apart
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ResearchNMR reveals sialic acid biosynthesis in real time
Using NMR, scientists can directly measure sialic acid enzyme conversion velocities for the first time
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ResearchWoodcock feathers’ nanostructure makes them the whitest ever found
The Eurasian woodcock’s white tail feathers reflect up to 55% of light –30% more than those of any other bird
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FeatureChanging the game in protein structure prediction
Have AlphaFold and other machine learning techniques essentially solved the formerly fiendish problem, or is there still more to be done? Clare Sansom reports
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ResearchProteins behind diatoms’ intricate nanoscale-patterned shells revealed
Finding could help pattern materials for photonics, catalysis and sensors
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OpinionExploring AlphaFold’s knowledge of energy landscapes
The algorithm needs a little help to find the global energy minimum
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ResearchNanoplastics disrupt ubiquitination in human cells
High-resolution study mapping nanoparticle–protein interactions builds understanding surrounding health implications of plastic contamination
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ResearchDiverse pharmaceutical building blocks prepared with evolved enzymes
Computation guides enzyme evolution to produce high-value drug compounds
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OpinionWhy glycans?
Glycoscience is turning out to be more interesting than anyone might have imagined
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OpinionWhy AlphaFold won’t revolutionise drug discovery
Protein structure prediction is a hard problem, but even harder ones remain
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ResearchTeixobactin’s two pronged antibiotic attack mechanism revealed
Understanding of formation of deadly supramolecular structures could help build improved antimicrobials
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NewsAlphaFold has predicted the structures of almost every known protein
Google offshoot DeepMind has released more than 200 million predicted 3D structures, covering nearly the entire protein universe