Structural biology – Page 4
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ResearchStructural studies offer glimpse of how coronavirus initiates human cell invasion
Researchers studying virus receptor-binding domains suggest virus could have passed directly from bats to humans
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ResearchDNA instructions pack proteins into unique crystal structures
Process could aid discovery of materials that exploit specific protein functions, such as drug molecules or biocatalysts
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ResearchPotent coronavirus drug candidate designed using 3D structure of key viral enzyme
Inhibitor of Sars-CoV-2 protease shows promise in early animal tests
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FeatureUncovering how the spliceosome makes the cut
Clare Sansom looks at the complex world of the spliceosome, a molecular machine in all our cells
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ResearchDetailed 3D coronavirus spike map offers hope for vaccine development
Structure determined at ‘remarkable’ speed in little over a month
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Research‘Chemical ear defenders’ could prevent hearing loss
Discovery of receptor connected to hearing loss has led to a chemical compound that can protect the neuromechanical machinery in mice’s ears
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ResearchSugars designed to disrupt bacterial cell wall biosynthesis
Rare monosaccharides explore concept for new narrow-spectrum antibiotics
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ResearchEngineered insulin with enhanced thermal stability inspired by fish-hunting snails
Four-disulfide insulin has similar bioactivity to native human insulin
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NewsSwipe right to help in the fight against Huntington’s disease
Citizen science project improves understanding of protein misfolding disorders like Huntington’s and Alzheimer’s diseases
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ResearchSecret of super-tough scales of giant Amazonian fish uncovered
Spiral-staircase structure prevents the scales being penetrated by piranhas
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OpinionRichard Henderson: ‘I rejected the phone call, and then noticed it was from Sweden…’
The 2017 laureate tells his story
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ResearchWhy photosynthetic organisms evolved to have dimeric reaction centres
Excitation energy transfer enhancements thought to compensate for decrease in charge transfer efficiency of going from monomers to dimers
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OpinionHas x-ray had its day?
Will the giant of structure determination be toppled by blasts from electron beams?
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OpinionBringing video games into the protein fold
Citizen scientists use a computer game to design brand new proteins
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ResearchSpore shell acts as sunscreen for light-sensitive antibiotics
Polymer capsule that protects and preserves antimicrobial compound could aid fight against multi-drug resistant pathogens
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ResearchNanoparticle-fed plankton grow magnetic skeletons
Scientists make bionic material by commandeering the growth process of a calcifying organism
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ResearchEnzyme evolved to selectively functionalise carbon–hydrogen bonds
Lactam libraries created by engineered bacterial enzyme offer new way to fight antibiotic resistance
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ResearchNeural network folds proteins a million times faster than its competitors
Machine learning algorithm that predicts protein structures in milliseconds could top next protein folding contest
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ResearchCracking enzyme structure offers new way to treat rare heart diseases
Solution was found by combining protein with its chaperone
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ResearchThe protein crystallisation influencer
Naomi Chayen discusses her career manipulating phase diagrams to produce high-quality protein crystals