Synthetic biology and molecular machines – Page 2
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ResearchCarbene chemistry built into microbe’s metabolism in first for biosynthesis
Proof-of-concept work opens pathway to bacteria engineered to synthesise new-to-nature products
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BusinessPfizer to buy cancer biotech Seagen for $43 billion
Antibody-drug conjugate specialist will fill Pfizer’s cancer pipeline
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ResearchBioelectric bacteria-powered sensor detects water contaminants in real time
Synthetic biology harnessed to detect endocrine disruptor and thiosulfate
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ResearchArtificially expanded genetic alphabet evolves enzymes for the first time
Libraries of short DNA sequences incorporating synthetic nucleotides perform better as enzymes than ordinary DNA
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CareersCarving out a career as an amateur scientist
Lacking a degree has not stopped Sebastian Cocioba making waves in the world of biotechnology
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ResearchDiverse pharmaceutical building blocks prepared with evolved enzymes
Computation guides enzyme evolution to produce high-value drug compounds
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ResearchNMR spectroscopy used to guide evolution of better enzymes
Identifying mutagenic ‘hotspots’ could speed development of new proteins
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OpinionNobel vision
Looking beyond the here-and-now let click chemistry open up a whole new world of possibility
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NewsExplainer: why have bioorthogonal and click chemistry won the 2022 Nobel prize?
Carolyn Bertozzi, Morten Meldal and Barry Sharpless have won the 2022 Nobel prize in chemistry – find out why
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ResearchYeast engineered to ferment sugars into chemotherapy drug precursors
Semisynthesis offers new route to anticancer drug vinblastine
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ResearchArtificially evolved enzyme tackles tricky cross coupling
Directed evolution on the metalloenzyme cytochrome P450 creates a catalyst for making macrocyclic antibiotics
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ResearchAI-engineered enzyme eats entire plastic containers
Enzyme with only five amino acid alterations depolymerises 51 different PET products faster and at lower temperature than other proteins
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ResearchYeast engineered to convert methanol into heparin
Production levels are currently low, but researchers hope the method could one day mean pharma doesn’t have to rely on animals for this essential medicine
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FeatureHow protocells bridge the gap from chemistry to biology
Rachel Brazil talks to the scientists trying to recreate what the first cells were like, or to make their own versions
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OpinionNed Seeman’s legacy
A system based on DNA ‘tiles’ can embody Darwinian evolution, raising new possibilities for understanding natural selection and materials development
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ResearchProkaryotes programmed to produce paracetamol avoid pervasive petrochemicals
Genetically modified E. coli serve as green factories for painkillers
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OpinionTaking the right inspiration from nature
Scientists need to be selective about their sources of inspiration
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Research‘Self-inflating’ synthetic cells can capture, store and release cargo
Entirely artificial system can use chemical energy to ‘swallow’ payloads like bacteria
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BusinessBrewing up plant-inspired medicines
Antheia reconstructs complex biochemical pathways in yeasts to speed up production of natural product-based drugs
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ResearchSortase A strategy could see ribosomal products reach further across chemical space
Compound libraries set to benefit from process that harnesses promiscuity of post-translation enzymes