Targeted protein degradation (TPD) refers to the use of small molecules to induce ubiquitin-dependent degradation of proteins. Due to their ability to address previously inaccessible targets, these degrader molecules are of great interest in drug development, although degrader discovery and optimisation remains an inefficient and empirical process due to a lack of understanding about the key molecular events required to successfully induce target degradation.

In this webinar, Nathanael Gray explains how chemo-proteomics can be used to annotate the ‘degradable kinome’. This work will fuel kinase degrader discovery and also provide a blueprint for evaluating targeted degradation across entire gene families, which will accelerate future understanding of TPD beyond the kinome.

By watching this webinar, you will have:

  • Learned about the challenges of protein degrader discovery
  • Gained an understanding about using chemo-proteomics to annotate the ‘degradable kinome’
  • Increased your understanding of target protein degradation for the kinome and beyond

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Nathanael Gray, professor at Harvard Medical School

Speaker: Nathanael Gray, professor, Harvard Medical School

Nathanael Gray is the Nancy-Lurie Marks professor of biological chemistry and molecular pharmacology at Harvard Medical School and the Dana-Farber Cancer Institute. He also leads the Dana-Farber program in chemical biology. Gray’s research centers on drug development and medicinal chemistry related to targeted therapies for cancer. Four drugs that he has had a hand in developing have already been approved in the US food and drug administration or are currently in clinical trials. Before joining Harvard and Dana-Farber, Gray was director of the Genomics Institute of the Novartis Research Foundation. He earned his PhD degree from the University of California, Berkeley, USA.

Ben Valsler

Moderator: Benjamin Valsler, digital editor, Chemistry World magazine

Ben is the digital editor of Chemistry World magazine, producing video and podcasts to accompany the magazine and website. Prior to joining the Royal Society of Chemistry, he was the producer of the award-winning Naked Scientists, making local and national radio programmes for the BBC, the Australian Broadcasting Corporation and Primedia in South Africa.

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